“Food Supplements
Whole food supplements are what their name suggests: Supplements made from concentrated whole foods. The vitamins found within these supplements are not isolated. They are highly complex structures that combine a variety of enzymes, coenzymes, antioxidants, trace elements, activators and many other unknown or undiscovered factors all working together synergistically, to enable this vitamin complex to do its job in your body.
Nutrients from within this complex cannot be taken apart or isolated from the whole, and then be expected to do the same job in the body as the whole complex is designed to do.
The perfect example of this difference can be seen in an automobile. An automobile is a wonderfully designed complex machine that needs all of its parts to be present and in place to function properly. Wheels are certainly an important part of the whole, but you could never isolate them from the rest of the car, call them a car or expect them to function like a car. They need the engine, body and everything else.
The same analogy applies to the vitamin C (ascorbic acid) or vitamin E (delta tocopherol) you can find on most health food store shelves. They are parts of an entire complex that serve a purpose when part of the whole. However, they cannot do the job of the entire complex by themselves.
With similar logic in place, one can analyze what a typical multivitamin truly is. The automobile equivalent of creating a multivitamin would be going to a junk yard, finding all of the separate parts you would need to make up an entire automobile, throwing them together in a heap (or capsule in terms of the multivitamin) and expecting that heap to drive like a car!
Obviously, there is a difference. Science cannot create life. Only life can create life.
Synthetic or Isolated Nutritional Supplements
Isolated nutrients or synthetic nutrients are not natural, in that they are never found by themselves in nature. Taking these isolated nutrients, especially at the ultra-high doses found in formulas today, is more like taking a drug. Studies show the body treats these isolated and synthetic nutrients like xenobiotics (foreign substances).
By the same token, food-based supplements are never treated like this by your body. For example, your urine will never turn florescent yellow, no matter how much meat (a good source of B vitamins) you eat. This sort of rapid excretion happens only with foreign substances in your body.
Not only are isolated nutrients treated like drugs or other chemicals by your body. Like drugs, they can create problems for you too. Nature does not produce any nutrient in an isolated form. The nutrients in foods are blended together in a specific way and work best in that format. For an isolated nutrient to work properly in the body, it needs all the other parts that are naturally present in the food too.
If the parts are not all there from the start, they are taken from the body’s stored supply. This is why isolated nutrients often work for a little while, then seem to stop working. Once your body’s store of the extra nutrients is used up, the isolated nutrient you’re taking doesn’t work as well anymore. Worse yet, a deficiency in these extra nutrients can be created in your body.
And, because most nutrients are isolated from the foods they come in — using a wide array of potentially nasty solvents and other chemicals — taking high amounts of these products can also expose you to these potentially toxic chemicals, if care is not taken to remove them. With the burden we are already facing from the high number of chemicals in our environment, why would anyone want to add more? “. 

Read more on http://articles.mercola.com/sites/articles/archive/2005/01/19/whole-food-supplements.aspx